Des (1-3) IGF-1 is a truncated variant of the IGF-1 hormone, engineered to have increased affinity for IGF receptors and more potent effects on muscle growth, tissue regeneration, and cellular repair. This modified version — which lacks the first three amino acids — binds less to inhibitory binding proteins in the bloodstream, increasing its local bioavailability.

Unlike IGF-1 LR3, which has a prolonged systemic effect, Des (1-3) IGF-1 acts more rapidly and locally, making it ideal for targeted muscle applications. Its shorter half-life (~20–30 minutes) is offset by its immediate and highly anabolic impact.

Benefits of Des (1-3) IGF-1
✔ Rapid muscle hypertrophy
✔ Enhanced cellular and tissue regeneration
✔ Effective muscle, tendon, and joint repair
✔ Targeted anabolic effects on injected muscle
✔ Increased vascularity and muscle density
✔ Direct stimulation of satellite cell proliferation

How to Use Des (1-3) IGF-1
Administration Method:
Intramuscular injection (preferably into the trained muscle) or subcutaneous (for limited systemic effects)

Recommended Dosage (for research purposes):
• Typical dose: 20–60 mcg per day
• Frequency: Once daily, ideally immediately post-workout
• Suggested cycle: 4–6 weeks, followed by a break

Best Practices for Des (1-3) IGF-1
• Post-workout application: Maximizes recovery and localized muscle growth
• Localized injection: Targeting the trained muscle may promote site-specific hypertrophy
• Avoiding insulin resistance: Less impact than LR3, but still advisable to pair with low-GI meals
• Storage: Keep refrigerated after reconstitution; use sterile techniques for handling and injection

Important Notes & Potential Side Effects
While highly anabolic, Des (1-3) IGF-1 should be used cautiously due to its potency and impact on cell division. Possible side effects include:
• Mild hypoglycemia – Less common than with LR3, but still possible
• Localized overgrowth – Uneven muscle development if poorly managed
• Injection site discomfort – Due to intense localized effect
• Unwanted tissue growth – Use with caution if predisposed to tumors or abnormal cell proliferation

Comparison Summary: IGF-1 LR3 vs Des (1-3) IGF-1